The San people , native tribe of the Kalahari Desert, have used Hoodia Gordonii for centuries, possibly even for thousands of years. The San Tribe is one of the oldest living tribes in the world. They have successfully used Hoodia Gordonii as an appetite and thirst suppressant in times of hunger, or when they needed to travel long distances without eating.

The San people —known for their survival skills, rock art, trance-dancing and mystic symbiosis with their semi-desert or savannah environment—can trace their heritage back some 27,000 years on the basis of rock paintings drawn by their ancestors.

Records said that other tribes in Africa, such as the Anikhwe (in Northern Botswana), the Hai Tribe (in Northen Namibia), and the Khomani tribe (in northwestern South Africa) have used Hoodia Gordonii in their tribal rituals, as a medicine and also as a food supplement.

But the contemporary history goes back to 1937, when a Dutch anthropologist studying the San indigenous people in the Kalahari desert noted that they sucked on the Hoodia plant as an appetite suppressant and thirst quencher.

These bushmen did not eat on their two to three day hunts; instead, they munched on the stem of this succulent to suppress their hunger and thirst.

Three decades ago, South African scientists at a government lab called the Council for Scientific and Industrial Research (CSIR) began studies on Hoodia effects in weight loss.

In 1966, the CSIR performed a study on what ate the san tribes, in order to determine any toxic effects for the plants they consumed. WHen they researched the hoodia gordonii on animales, they noticed hoodia gordonii not only did not generate any toxic effects, but on animals, the hoodia gordonii helped lose weight. After several trials, they discovered when they feed the animales, they lose weight.  

By 1967, the CSIR researchers isolated the bioactive compound in hoodia gordonii responsible for appetite suppression and obtained a patent.

Several years later, the CSIR licensed the  patent to a british herbal research company, Phytopharm which renamed the molecule as P57, being the 57th product on what Phytopharm researched and poured money on.

In the meantime, and after some research conducted by Phytopharm, they sold the rights to Pfizer to develop a weight loss diet pill. After several months, Pfizer returned the rights to Phytopharm, and then, after a certain period, in December 2004, the british company licensed the rights to food giant Unilever, to manufacture and market diet foods instead of diet pills in the near future.

Up to date, Unilever does not have any product on the market. However, hundred of hoodia diet pills are on sale, manufactured by other companies.

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